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The biological and clinical significance of stromal-epithelial interactions in breast cancer

McCuaig, Robert; Wu, Fan; Dunn, J; Rao, Sudha; Dahlstrom, Jane


There is evidence that an aberrant tumour microenvironment (TME) facilitates cancer development, progression, and responses to treatment. While many of the mechanisms underlying the phenotype and cancer-promoting behaviour of the TME are unknown, epigenetic mechanisms in cancer cells and the TME are thought to play important roles. As a result, cancer profiling strategies for drug and biomarker development require a thorough understanding of both the epithelial tissue compartment and the...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
Source: Pathology
DOI: 10.1016/j.pathol.2016.10.009
Access Rights: Open Access


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