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The association of falling insulin requirements with maternal biomarkers and placental dysfunction: A prospective study of women with preexisting diabetes in pregnancy

Padmanabhan, Suja; Lee, Vincent W. S; Mclean, Marc; Athayde, Neil; Lanzarone, V; Khoshnow, Qemer; Peek, Michael; Cheung, N Wah


OBJECTIVE To investigate the association of falling insulin requirements (FIR) among women with preexisting diabetes with adverse obstetric outcomes and maternal biomarkers longitudinally in pregnancy. RESEARCH DESIGN AND METHODS A multicenter prospective cohort study of 158 women (41 with type 1 diabetes and 117 with type 2 diabetes) was conducted. Women with FIR of ≥15% from the peak total daily dose after 20 weeks' gestation were considered case subjects (n = 32). The primary outcome was a...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
Source: Diabetes Care
DOI: 10.2337/dc17-0391


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