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The angiotensin receptor blocker, Losartan, inhibits mammary tumor development and progression to invasive carcinoma

Coulson, Rhiannon; Liew, Seng; Connelly, Angela; Yee, Nicholas; Deb, Siddhartha; Kumar, Beena; Vargas, Ana; O'Toole, Sandra; Parslow, Adam; Poh, Ashleigh; Putoczki, Tracy; Morrow, Riley; Alorro, Mariah; Lazarus, Kyren; Yeap, Evie; Walton, Kelly; Harrison, Craig; Hannan, Natalie; George, Amee; Clyne, Colin; Ernst, Matthias; Allen, Andrew; Chand, Ashwini

Description

Drugs that target the Renin-Angiotensin System (RAS) have recently come into focus for their potential utility as cancer treatments. The use of Angiotensin Receptor Blockers (ARBs) and Angiotensin-Converting Enzyme (ACE) Inhibitors (ACEIs) to manage hypertension in cancer patients is correlated with improved survival outcomes for renal, prostate, breast and small cell lung cancer. Previous studies demonstrate that the Angiotensin Receptor Type I (AT1R) is linked to breast cancer pathogenesis,...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
URI: http://hdl.handle.net/1885/248706
Source: Oncotarget
DOI: 10.18632/oncotarget.15553
Access Rights: Open Access

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