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Synthetically controlling dendrimer flexibility improves delivery of large plasmid DNA

Kretzmann, Jessica A.; Ho, Diwei; Evans, Cameron; Plani-Lam, Janice Hiu Chor; Garcia-Bloj, Benjamin; Mohamed, Ahmed Elaaf; O'Mara, Megan; Ford, Ethan A.; Tan, Dennis E K; Lister, Ryan; Blancafort, Pilar; Norret, Marck; Iyer, Swaminathan


Tools for editing the genome and epigenome have revolutionised the field of molecular biology and represent a new frontier in targeted therapeutic intervention. Although efficiencies and specificities of genome editing technologies have improved with the development of TALEs and CRISPR platforms, intracellular delivery of these larger constructs still remains a challenge using existing delivery agents. Viral vectors, including lentiviruses and adeno-associated viruses, as well as some non-viral...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
Source: Chemical Science
DOI: 10.1039/c7sc00097a
Access Rights: Open Access


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