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Granzyme B is expressed in mouse mast cells in vivo and in vitro and causes delayed cell death independent of perforin

Pardo, Julian; Wallich, R; Ebnet, K; Iden, S; Zentgraf, H; Martin, P; Ekiciler, A; Prins, Anne; Mullbacher, Arno; Huber, M; Simon, Markus M


Mast cells respond to pathogens and allergens by secreting a vast array of preformed and newly synthesized mediators, including enzymes, vasoactive amines, lipid mediators, cytokines and chemokines, thereby affecting innate and adaptive immune responses and pathogenesis. Here, we present evidence that skin-, but not lung-associated primary mast cells as well as in vitro-differentiated bone marrow-derived mast cells (BMMC) express granzyme (gzm) B, but not gzmA or perforin (perf). GzmB is...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Cell Death and Differentiation
DOI: 10.1038/sj.cdd.4402183


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