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Ca2+ signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin

Beard, Nicole; Wei, L; Dulhunty, Angela


This review focuses on molecular interactions between calsequestrin, triadin, junctin and the ryanodine receptor in the lumen of the sarcoplasmic reticulum. These interactions modulate changes in Ca2+ release in response to changes in the Ca2+ load within the sarcoplasmic reticulum store in striated muscle and are of fundamental importance to Ca 2+ homeostasis, since massive adaptive changes occur when expression of the proteins is manipulated, while mutations in calsequestrin lead to...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: European Biophysics Journal
DOI: 10.1007/s00249-009-0449-6


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