Ryanodine receptor modification and regulation by intracellular Ca2?+ and Mg2?+ in healthy and failing human hearts
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Walweel, K; Molenaar, Peter; Imtiaz, M S; Denniss, A; dos Remedios, Cristobal; vanHelden, Dirk F; Dulhunty, Angela; Laver, Derek R; Beard, Nicole
Description
Rationale: Heart failure is a multimodal disorder, of which disrupted Ca2 + homeostasis is a hallmark. Central to Ca2 + homeostasis is the major cardiac Ca2 + release channel – the ryanodine receptor (RyR2) – whose activity is influenced by associated proteins, covalent modification and by Ca2 + and Mg2 +. That RyR2 is remodelled and its function disturbed in heart failure is well recognized, but poorly understood. Objective: To assess Ca2 + and Mg2 + regulation of RyR2 from left ventricles of...[Show more]
Collections | ANU Research Publications |
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Date published: | 2017 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/247844 |
Source: | Journal of Molecular and Cellular Cardiology |
DOI: | 10.1016/j.yjmcc.2017.01.016 |
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File | Description | Size | Format | Image |
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01_Walweel_Ryanodine_receptor_2017.pdf | 1.23 MB | Adobe PDF | Request a copy |
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