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Role of the IL-1 Pathway in Dopaminergic Neurodegeneration and Decreased Voluntary Movement

Stojakovic, Andrea; Da Paz Filho, Gilberto; Arcos-Burgos, Mauricio; Licinio, Julio; Wong, Ma-Li; Mastronardi, Claudio


Interleukin-1 (IL-1), a proinflammatory cytokine synthesized and released by activated microglia, can cause dopaminergic neurodegeneration leading to Parkinson’s disease (PD). However, it is uncertain whether IL-1 can act directly, or by exacerbating the harmful actions of other brain insults. To ascertain the role of the IL-1 pathway on dopaminergic neurodegeneration and motor skills during aging, we compared mice with impaired [caspase-1 knockout (casp1−/−)] or overactivated IL-1 activity...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
Source: Molecular Neurobiology
DOI: 10.1007/s12035-016-9988-x
Access Rights: Open Access


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