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Development of Biomarkers for Inhibition of SLC6A19 - A Potential Target to treat Metabolic Disorders

Javed, Kiran

Description

Dietary protein restriction has beneficial impacts on metabolic health. SLC6A19 (B0AT1) is the major transporter of neutral amino acids at the intestinal epithelium and absorbs the bulk of the diet-derived neutral amino acids from the intestinal lumen. It also reabsorbs neutral amino acids in the renal proximal tubules. Mice lacking SLC6A19 show signs of protein restriction, such as high FGF21 levels and low mTORC1 activity. Moreover, they have improved glucose homeostasis and resist...[Show more]

CollectionsOpen Access Theses
Date published: 2021
Type: Thesis (PhD)
URI: http://hdl.handle.net/1885/247802
DOI: 10.25911/H9VY-WY66

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