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PTPN2-deficiency exacerbates T follicular helper cell and B cell responses and promotes the development of autoimmunity

Wiede, Florian; Sacirbegovic, Faruk; Leong, Yew Ann; Yu, Di; Tiganis, Tony

Description

Non-coding single nucleotide polymorphisms that repress PTPN2 expression have been linked with the development of type 1 diabetes, rheumatoid arthritis and Crohn's disease. PTPN2 attenuates CD8þ T cell responses to self and prevents overt autoreactivity in the context of T cell homeostasis and antigen crosspresentation. The role of PTPN2 in other immune subsets in the development of autoimmunity remains unclear. Here we show that the inducible deletion of PTPN2 in hematopoietic compartment of...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
URI: http://hdl.handle.net/1885/247414
Source: Journal of Autoimmunity
DOI: 10.1016/j.jaut.2016.09.004

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