PTPN2-deficiency exacerbates T follicular helper cell and B cell responses and promotes the development of autoimmunity
Non-coding single nucleotide polymorphisms that repress PTPN2 expression have been linked with the development of type 1 diabetes, rheumatoid arthritis and Crohn's disease. PTPN2 attenuates CD8þ T cell responses to self and prevents overt autoreactivity in the context of T cell homeostasis and antigen crosspresentation. The role of PTPN2 in other immune subsets in the development of autoimmunity remains unclear. Here we show that the inducible deletion of PTPN2 in hematopoietic compartment of...[Show more]
|Collections||ANU Research Publications|
|Source:||Journal of Autoimmunity|
|01_Wiede_PTPN2-deficiency_exacerbates_T_2017.pdf||4.79 MB||Adobe PDF||Request a copy|
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.