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Prognostic significance of KIT exon 11 deletion mutation in intermediate-risk gastrointestinal stromal tumor

Quek, Richard; Farid, Mohamad; Kanjanapan, Yada; Lim, Cindy; Tan, Iain Beehuat; Kesavan, Sittampalam; Lim, Tony Kiat Hon; Oon, Lynette Lin-Ean; Goh, Brian K P; Chan, Weng Hoong; Teo, Melissa; Yip, Desmond

Description

Aim: Benefit of adjuvant imatinib therapy following curative resection in patients with intermediate-risk gastrointestinal stromal tumor (GIST) is unclear. GIST-specific exon mutations, in particular exon 11 deletions, have been shown to be prognostic. We hypothesize that specific KIT mutations may improve risk stratification in patients with intermediate-risk GIST, identifying a subgroup of patients who may benefit from adjuvant therapy. Methods: In total, 142 GIST patients with complete...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
URI: http://hdl.handle.net/1885/247362
Source: Asia-Pacific Journal of Clinical Oncology
DOI: 10.1111/ajco.12603

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