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Platelets in Malarial Infection: Protective or Pathological?

Foote, Simon; Burgio, Gaetan; McMorran, Brendan


Platelets play an ambiguous role in a malarial infection. On the one hand, platelets have been implicated adversely in cerebral malaria. They stick to the cerebral endothelium and mediate the adhesion of infected erythrocytes, with the postulated outcome of increasing severity or of even mediating this disease. On the other hand, platelets bind to infected red cells in the periphery and activate and release the cytokine PF4. This, in turn, binds to the Duffy antigen on the red cell and is...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Book chapter
Book Title: Platelets in Thrombotic and Non-Thrombotic Disorders
DOI: 10.1007/978-3-319-47462-5_73


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