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Platelet Adhesion

Gardiner, Elizabeth; Andrews, Robert

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Platelet adhesion is a critical functional component of blood platelets in pathophysiology and a current focus of drugs modulating platelet activity. In this chapter, we discuss platelet adhesion in terms of both basic science and clinical relevance, not only related to thrombosis and haemostasis, but also in terms of inflammation, infection, and immune-related functions of platelets. In particular, a key factor in the initiation and control of platelet adhesion in the healthy or diseased...[Show more]

dc.contributor.authorGardiner, Elizabeth
dc.contributor.authorAndrews, Robert
dc.contributor.editorGresele, P.
dc.contributor.editorKleiman, Neal S.
dc.contributor.editorLopez, Jose A
dc.contributor.editorPage, Clive P
dc.date.accessioned2021-09-01T04:07:17Z
dc.identifier.isbn9783319474601
dc.identifier.urihttp://hdl.handle.net/1885/247297
dc.description.abstractPlatelet adhesion is a critical functional component of blood platelets in pathophysiology and a current focus of drugs modulating platelet activity. In this chapter, we discuss platelet adhesion in terms of both basic science and clinical relevance, not only related to thrombosis and haemostasis, but also in terms of inflammation, infection, and immune-related functions of platelets. In particular, a key factor in the initiation and control of platelet adhesion in the healthy or diseased bloodstream is the effect of changes in fluid shear forces, which is also essential in control of expression and regulation of platelet-specific receptors such as glycoprotein (GP) Ib-IX-V and GPVI, and the interactions with their major binding partners, including von Willebrand factor (VWF) and collagen, respectively. It is the nature of human platelets to rapidly become adhesive to various cellular or non-cellular substrates and to secrete an array of prothrombotic and proinflammatory factors, to localize coagulation and neutrophil-mediated inflammation within the vasculature. Understanding the cellular, biochemical, and shear-related mechanisms involved in platelet adhesion can underpin new advances in the diagnosis and therapy of disease.
dc.description.sponsorshipWe thank the National Health and Medical Research Council (NH&MRC), Australia, for financial support.
dc.format.mimetypeapplication/pdf
dc.language.isoen_AU
dc.publisherSpringer International Publishing AG
dc.relation.ispartofPlatelets in Thrombotic and Non-Thrombotic Disorders
dc.rights© Springer International Publishing AG 2017
dc.titlePlatelet Adhesion
dc.typeBook chapter
local.description.notesImported from ARIES
dc.date.issued2017
local.identifier.absfor060110 - Receptors and Membrane Biology
local.identifier.ariespublicationu3355791xPUB9
local.publisher.urlhttps://link.springer.com/
local.type.statusPublished Version
local.contributor.affiliationGardiner, Elizabeth, College of Health and Medicine, ANU
local.contributor.affiliationAndrews, Robert, Monash University
local.description.embargo2099-12-31
local.bibliographicCitation.startpage309
local.bibliographicCitation.lastpage319
local.identifier.doi10.1007/978-3-319-47462-5_23
local.identifier.absseo970106 - Expanding Knowledge in the Biological Sciences
dc.date.updated2020-11-23T10:56:56Z
local.bibliographicCitation.placeofpublicationSwitzerland
CollectionsANU Research Publications

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