P-glycoprotein Inhibition: The Past, the Present and the Future
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Darby, Richard A. J.; McMahon, Roisin M.; Callaghan, Richard
Description
The multidrug resistant phenotype of cancer cells can often result from the over-production of a number of ATP binding cassette (ABC) transporters, including P-glycoprotein (P-gp). These multidrug efflux transporters expel administered anti-cancer drugs from the cancer cell, preventing sufficient intracellular drug accumulation and ultimately, drug efficacy. The co-administration of compounds that can impede the efflux of chemotherapeutic agents by these ABC transporters can concomitantly...[Show more]
Collections | ANU Research Publications |
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Date published: | 2011 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/24722 |
Source: | Current Drug Metabolism |
DOI: | 10.2174/138920011798357006 |
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