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Computational analyses show A-to-G mutations correlate with nascent mRNA hairpins at somatic hypermutation hotspots

Steele, Edward J; Lindley, Robyn A; Wen, Jiayu; Weiller, Georg


Activation-induced cytidine deaminase (AID) initiates Phase I somatic hypermutation (SHM) of antibody genes by deaminating deoxy-cytosine to deoxy-uracil (C-to-U). These lesions trigger Phase II, a poorly understood process of error-prone repair targeting A-T pairs by DNA polymerase η (Pol η). Since Pol η is also a reverse transcriptase, Phase II could involve copying off RNA as well as DNA templates. We explore this idea further since in an RNA-based pathway it is conceivable that...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: DNA Repair
DOI: 10.1016/j.dnarep.2006.06.002


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