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Residual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosis

Sutton, Vivien R; Waterhouse, Nigel J; Browne, Kylie; Sedelies, Karin; Ciccone, Annette; Anthony, Desiree A; Koskinen, Aulikki; Mullbacher, Arno; Trapani, Joseph A


Cathepsin C activates serine proteases expressed in hematopoietic cells by cleaving an N-terminal dipeptide from the proenzyme upon granule packaging. The lymphocytes of cathepsin C-null mice are therefore proposed to totally lack granzyme B activity and

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Journal of Cell Biology
DOI: 10.1083/jcb.200609077


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