Evidence and consequences of spectrum bias in studies of criteria for liver transplant in paracetamol hepatotoxicity
Objective: In severe paracetamol hepatotoxicity, orthotopic liver transplant (OLT) is a standard treatment in patients judged to have a hopeless prognosis. The most commonly used criteria to make this decision are the King's College Criteria (KCC). We aimed to compare the expected survival for patients who meet the KCC and do not receive transplant and those who receive OLT. Methods: A systematic review of studies of survival in patients who met the KCC according to whether they were...[Show more]
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