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Outbreak of health care-associated Burkholderia cenocepacia bacteremia and infection attributed to contaminated sterile gel used for central line insertion under ultrasound guidance and other procedures

Shaban, Ramon Z; Maloney, Samuel; Gerrard, John; Collignon, Peter; Macbeth, Deborough; Cruickshank, Marilyn; Hume, Anna; Jennison, Amy; Graham, Rikki M A; Bergh, Haakon; Wilson, Heather; Derrington, Petra

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Background: We report an outbreak of Burkholderia cenocepacia bacteremia and infection in 11 patients predominately in intensive care units caused by contaminated ultrasound gel used in central line insertion and sterile procedures within 4 hospitals across Australia. Methods: Burkholderia cenocepacia was first identified in the blood culture of a patient from the intensive care unit at the Gold Coast University Hospital on March 26, 2017, with 3 subsequent cases identified by April 7, 2017....[Show more]

dc.contributor.authorShaban, Ramon Z
dc.contributor.authorMaloney, Samuel
dc.contributor.authorGerrard, John
dc.contributor.authorCollignon, Peter
dc.contributor.authorMacbeth, Deborough
dc.contributor.authorCruickshank, Marilyn
dc.contributor.authorHume, Anna
dc.contributor.authorJennison, Amy
dc.contributor.authorGraham, Rikki M A
dc.contributor.authorBergh, Haakon
dc.contributor.authorWilson, Heather
dc.contributor.authorDerrington, Petra
dc.date.accessioned2021-08-26T05:52:16Z
dc.identifier.issn0196-6553
dc.identifier.urihttp://hdl.handle.net/1885/245663
dc.description.abstractBackground: We report an outbreak of Burkholderia cenocepacia bacteremia and infection in 11 patients predominately in intensive care units caused by contaminated ultrasound gel used in central line insertion and sterile procedures within 4 hospitals across Australia. Methods: Burkholderia cenocepacia was first identified in the blood culture of a patient from the intensive care unit at the Gold Coast University Hospital on March 26, 2017, with 3 subsequent cases identified by April 7, 2017. The outbreak response team commenced investigative measures. Results: The outbreak investigation identified the point source as contaminated gel packaged in sachets for use within the sterile ultrasound probe cover. In total, 11 patient isolates of B cenocepacia with the same multilocus sequence type were identified within 4 hospitals across Australia. This typing was the same as identified in the contaminated gel isolate with single nucleotide polymorphism-based typing, demonstrating that all linked isolates clustered together. Conclusion: Arresting the national point-source outbreak within multiple jurisdictions was critically reliant on a rapid, integrated, and coordinated response and the use of informal professional networks to first identify it. All institutions where the product is used should look back at Burkholderia sp blood culture isolates for speciation to ensure this outbreak is no larger than currently recognized given likely global distribution.
dc.format.mimetypeapplication/pdf
dc.language.isoen_AU
dc.publisherElsevier
dc.rights© 2017 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc
dc.sourceAmerican Journal of Infection Control
dc.subjectHospital-associated infections
dc.subjectHealth care-associated infection
dc.subjectContamination
dc.subjectCannulation
dc.titleOutbreak of health care-associated Burkholderia cenocepacia bacteremia and infection attributed to contaminated sterile gel used for central line insertion under ultrasound guidance and other procedures
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume45
dc.date.issued2017
local.identifier.absfor060504 - Microbial Ecology
local.identifier.ariespublicationu5234101xPUB49
local.publisher.urlhttps://www.elsevier.com/en-au
local.type.statusPublished Version
local.contributor.affiliationShaban, Ramon Z, Menzies Health Institute Queensland
local.contributor.affiliationMaloney, Samuel, Pathology Queensland
local.contributor.affiliationGerrard, John, Gold Coast University Hospital
local.contributor.affiliationCollignon, Peter, College of Health and Medicine, ANU
local.contributor.affiliationMacbeth, Deborough, Gold Coast Hospital and Health Service
local.contributor.affiliationCruickshank, Marilyn, Griffith University
local.contributor.affiliationHume, Anna, Pathology Queensland
local.contributor.affiliationJennison, Amy, Queensland Department of Health
local.contributor.affiliationGraham, Rikki M A, Department of Health
local.contributor.affiliationBergh, Haakon, Pathology Queensland
local.contributor.affiliationWilson, Heather, College of Health and Medicine, ANU
local.contributor.affiliationDerrington, Petra, Pathology Queensland
local.description.embargo2099-12-31
local.bibliographicCitation.issue9
local.bibliographicCitation.startpage954
local.bibliographicCitation.lastpage958
local.identifier.doi10.1016/j.ajic.2017.06.025
local.identifier.absseo970111 - Expanding Knowledge in the Medical and Health Sciences
dc.date.updated2020-11-23T10:55:01Z
local.identifier.scopusID2-s2.0-85026289513
CollectionsANU Research Publications

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