Abdellatif , Yasser; Liu, Dan; Gallant, Esther; Gage, Peter; Board, Philip; Dulhunty, Angela
Members of the glutathione transferase (GST) structural family are novel regulators of cardiac ryanodine receptor (RyR) calcium channels. We present the first detailed report of the effect of endogenous muscle GST on skeletal and cardiac RyRs. An Mu class glutathione transferase is specifically expressed in human muscle. An hGSTM2-2-like protein was isolated from rabbit skeletal muscle and sheep heart, at concentrations of ∼17-93 μM. When added to the cytoplasmic side of RyRs, hGSTM2-2 and GST...[Show more]
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