Accumulation and distribution of doxorubicin in tumour spheroids: the influence of acidity and expression of P-glycoprotein
Purpose: The intra-tumour distribution of anticancer drugs remains an important, but often under-estimated, influence on drug efficacy. Tumour acidity and the presence of efflux pumps were examined for their influence on the distribution of doxorubicin in a solid tumour model. Methods: Anticancer drug distribution and overall accumulation was measured in tumour spheroids (TS) of varying sizes. The distribution profiles were examined in normoxic and hypoxic TS, the latter generating metabolic...[Show more]
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|Source:||Cancer Chemotherapy and Pharmacology|
|01_Mellor_Accumulation_and_distribution_2011.pdf||2.02 MB||Adobe PDF||Request a copy|
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