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Accumulation and distribution of doxorubicin in tumour spheroids: the influence of acidity and expression of P-glycoprotein

Mellor, Howard R.; Callaghan, Richard


Purpose: The intra-tumour distribution of anticancer drugs remains an important, but often under-estimated, influence on drug efficacy. Tumour acidity and the presence of efflux pumps were examined for their influence on the distribution of doxorubicin in a solid tumour model. Methods: Anticancer drug distribution and overall accumulation was measured in tumour spheroids (TS) of varying sizes. The distribution profiles were examined in normoxic and hypoxic TS, the latter generating metabolic...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Cancer Chemotherapy and Pharmacology
DOI: 10.1007/s00280-011-1598-8


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