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Tracing the action of IL-2 in tolerance to islet-sepcific antigen

Liston, Adrian; Siggs, Owen; Goodnow, Christopher


Genetic variants of interleukin 2 (IL-2) and its receptor are associated with murine and human susceptibility to Type 1 diabetes, yet the role of IL-2 in controlling pancreatic islet-reactive T cells is unknown. Here, we develop a model where IL-2 deficiency precipitates a breakdown of self-tolerance and progression to diabetes, and its action upon diabetogenic islet-specific CD4 T cells can be tracked. We find that IL-2 is not required for Aire-dependent thymic clonal deletion of high-avidity...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Immunology and Cell Biology
DOI: 10.1038/sj.icb.7100049


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