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Neutrophil-mediated IL-6 receptor trans-signaling and the risk of chronic obstructive pulmonary disease and asthma

Farahi, Neda; Paige, Ellie; Balla, Jozef; Prudence, Emily; Ferreira, Ricardo; southwood, Mark; Appleby, Sarah L; Bakke, Per; Gulsvik, Amund; Litonjua, Augusto A; Sparrow, David; Silverman, Edwin K; Cho, Michael H; Danesh, John; Paul, Dirk S; Freitag, Daniel; Chilvers, Edwin R


The Asp358Ala variant in the interleukin-6 receptor (IL-6R) gene has been implicated in asthma, autoimmune and cardiovascular disorders, but its role in other respiratory conditions such as chronic obstructive pulmonary disease (COPD) has not been investigated. The aims of this study were to evaluate whether there is an association between Asp358Ala and COPD or asthma risk, and to explore the role of the Asp358Ala variant in sIL-6R shedding from neutrophils and its pro-inflammatory effects in...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
Source: Human Molecular Genetics
DOI: 10.1093/hmg/ddx053
Access Rights: Open Access


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