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Multiple targets for flecainide action: Implications for cardiac arrhythmogenesis

Salvage, Samantha C.; Chandrasekharan, Karthik H; Jeevaratnam, Kamalan; Dulhunty, Angela; Thompson, Andrew J; Jackson, Antony P.; Huang, Christopher


Flecainide suppresses cardiac tachyarrhythmias including paroxysmal atrial fibrillation, supraventricular tachycardia and arrhythmic long QT syndromes (LQTS), as well as the Ca2+-mediated, catecholaminergic polymorphic ventricular tachycardia (CPVT). However, flecainide can also exert pro-arrhythmic effects most notably following myocardial infarction and when used to diagnose Brugada syndrome (BrS). These divergent actions result from its physiological and pharmacological actions at multiple,...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
Source: British Journal of Pharmacology
DOI: 10.1111/bph.13807


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