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Multiple functional self-association interfaces in plant TIR domains

Zhang, XiaoXiao; Bernoux, Maud; Bentham, Adam; Newman, Toby E.; Ve, Thomas; Casey, Lachlan W.; Raaymakers, Tom M.; Hu, Jian; Croll, Tristan I.; Schreiber, Karl; Staskawiczj, Brian J.; Williams, Simon

Description

Toll/interleukin-1 receptor/resistance protein (TIR) domains are present in plant and animal innate immunity receptors and appear to play a scaffold function in defense signaling. In both systems, self-association of TIR domains is crucial for their function. In plants, the TIR domain is associated with intracellular immunity receptors, known as nucleotide-binding oligomerization domain-like receptors (NLRs). Previous studies from several plant NLRs have identified two distinct interfaces that...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
URI: http://hdl.handle.net/1885/243965
Source: PNAS - Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.1621248114
Access Rights: Open Access

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