Skip navigation
Skip navigation

Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression

Culverhouse, Robert C; Saccone, Nancy L; Horton, AC; Anstey, Kaarin; Banaschewski, T; Burmeister, Margit; Cohen-Woods, S; Etain, B; Fisher, HL; Goldman, N; Guillame, S; Easteal, Simon

Description

The hypothesis that the S allele of the 5-HTTLPR serotonin transporter promoter region is associated with increased risk of depression, but only in individuals exposed to stressful situations, has generated much interest, research and controversy since first proposed in 2003. Multiple meta-analyses combining results from heterogeneous analyses have not settled the issue. To determine the magnitude of the interaction and the conditions under which it might be observed, we performed new analyses...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
URI: http://hdl.handle.net/1885/243872
Source: Molecular Psychiatry
DOI: 10.1038/mp.2017.44
Access Rights: Open Access

Download

File Description SizeFormat Image
nihms849357.pdf1.11 MBAdobe PDFThumbnail


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator