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NMR structure determination of protein - ligand complexes by lanthanide labeling

Pintacuda, Guido; John, Michael; Su, Xun-Cheng; Otting, Gottfried


The paramagnetism of lanthanide ions offers outstanding opportunities for fast determinations of the three-dimensional (3D) structures of protein-ligand complexes by nuclear magnetic resonance (NMR) spectroscopy. It is shown how the combination of pseudocontact shifts (PCSs) induced by a site-specifically bound lanthanide ion and prior knowledge of the 3D structure of the lanthanide-labeled protein can be used to achieve (i) rapid assignments of NMR spectra, (ii) structure determinations of...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Accounts of Chemical Research
DOI: 10.1021/ar050087z


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