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MMP2 and MMP9 associate with crescentic glomerulonephritis

Phillips, Tessa; Fadia, Mitali; Lea-Henry, Tom N; Smiles, J A; Walters, Giles; Jiang, Simon


Background: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by multiple organ involvement. Lupus nephritis (LN) is a common manifestation with a wide variety of histological appearances. Matrix metalloproteinases (MMP) 2 and 9 are gelatinases capable of degrading glomerular basement membrane type IV collagen, which have been associated with LN. We examine the expression of MMP2 and MMP9 in different classes of LN. Methods: MMP2 and MMP9 expression was detected...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
Source: Clinical Kidney Journal
DOI: 10.1093/ckj/sfw111
Access Rights: Open Access


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