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Memory Resilience to Alzheimer's Genetic Risk: Sex Effects in Predictor Profiles

McDermott, Kirstie L; McFall, G. Peggy; Andrews, Shea; Anstey, Kaarin; Dixon, Roger A.

Description

Objectives: Apolipoprotein E (APOE) ɛ4 and Clusterin (CLU) C alleles are risk factors for Alzheimer’s disease (AD) and episodic memory (EM) decline. Memory resilience occurs when genetically at-risk adults perform at high and sustained levels. We investigated whether (a) memory resilience to AD genetic risk is predicted by biological and other risk markers and (b) the prediction profiles vary by sex and AD risk variant. Method: Using a longitudinal sample of nondemented adults (n = 642, aged...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
URI: http://hdl.handle.net/1885/243250
Source: International Journal of Gerontology
DOI: 10.1093/geronb/gbw161

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