Maternal hypertensive disorders are associated with increased use of respiratory support but not chronic lung disease or poorer neurodevelopmental outcomes in preterm neonates at < 29 weeks of gestation
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Matic, Mara; Inati, Violet; Mohamed, Abdel-Latif; Kent, Alison
Description
Aim To assess whether maternal hypertensive disorders in pregnancies result in higher respiratory requirements, risk of chronic lung disease (CLD) and poorer neurodevelopmental outcome in <29-week premature neonates. MethodsThis is a multicentre, retrospective cohort study, within a geographically defined area in Australia, served by a network of 10 neonatal intensive care units (NICUs), consisting of infants <29 weeks of gestational age who were admitted to NICUs between 1998 and 2004....[Show more]
dc.contributor.author | Matic, Mara | |
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dc.contributor.author | Inati, Violet | |
dc.contributor.author | Mohamed, Abdel-Latif | |
dc.contributor.author | Kent, Alison | |
dc.date.accessioned | 2021-08-05T03:48:30Z | |
dc.identifier.issn | 1034-4810 | |
dc.identifier.uri | http://hdl.handle.net/1885/242826 | |
dc.description.abstract | Aim To assess whether maternal hypertensive disorders in pregnancies result in higher respiratory requirements, risk of chronic lung disease (CLD) and poorer neurodevelopmental outcome in <29-week premature neonates. MethodsThis is a multicentre, retrospective cohort study, within a geographically defined area in Australia, served by a network of 10 neonatal intensive care units (NICUs), consisting of infants <29 weeks of gestational age who were admitted to NICUs between 1998 and 2004. Outcome measures included hospital survival, perinatal complications and functional disability at 2-3 years follow-up. ResultsA total of 2549 mothers and infants were included in the study; 379 (14.9%) mothers had hypertensive disorders during pregnancy. Follow-up data were obtained for 1473 (74.8%) infants at 2-3 years. Infants exposed to pre-eclampsia had a higher need for supplemental surfactant therapy (odds ratio (OR): 2.004, 95% confidence interval (CI): 1.51-2.66), longer duration of mechanical ventilation (7.0 days vs. 4.0 days), were associated with a higher incidence of CLD (OR: 1.40, 95% CI: 1.12-1.76) and received post-natal steroids for CLD (OR: 1.82, 95% CI: 1.43-2.31) and home oxygen (OR: 1.47, 95% CI: 1.11-1.95). Multivariable analysis showed that hypertensive disease of pregnancy was not significantly associated with the development of CLD in this cohort (OR: 1.103, 95% CI: 0.845-1.441). Multivariable analysis of long-term neurodevelopmental data available for the 1473 follow-up infants showed no significant difference in outcomes with or without exposure to maternal hypertensive disease. Conclusion Maternal hypertensive disease of pregnancy does not increase the risk of CLD or long-term neurodevelopmental complications in infants born at <29 weeks of gestation. | |
dc.format.mimetype | application/pdf | |
dc.language.iso | en_AU | |
dc.publisher | Wiley | |
dc.rights | © 2017 Paediatrics and Child Health Division (The Royal Australasian College of Physicians) | |
dc.source | Journal of Paediatrics and Child Health | |
dc.subject | chronic lung disease | |
dc.subject | neurodevelopment | |
dc.subject | pre-eclampsia | |
dc.subject | preterm neonate | |
dc.title | Maternal hypertensive disorders are associated with increased use of respiratory support but not chronic lung disease or poorer neurodevelopmental outcomes in preterm neonates at < 29 weeks of gestation | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.identifier.citationvolume | 53 | |
dc.date.issued | 2017 | |
local.identifier.absfor | 111499 - Paediatrics and Reproductive Medicine not elsewhere classified | |
local.identifier.ariespublication | u5369653xPUB140 | |
local.publisher.url | https://www.wiley.com/en-gb | |
local.type.status | Published Version | |
local.contributor.affiliation | Matic, Mara, College of Health and Medicine, ANU | |
local.contributor.affiliation | Inati, Violet, College of Health and Medicine, ANU | |
local.contributor.affiliation | Mohamed, Abdel-Latif, College of Health and Medicine, ANU | |
local.contributor.affiliation | Kent, Alison, College of Health and Medicine, ANU | |
local.description.embargo | 2099-12-31 | |
local.bibliographicCitation.issue | 4 | |
local.bibliographicCitation.startpage | 391 | |
local.bibliographicCitation.lastpage | 398 | |
local.identifier.doi | 10.1111/jpc.13430 | |
local.identifier.absseo | 920100 - CLINICAL HEALTH (ORGANS, DISEASES AND ABNORMAL CONDITIONS) | |
dc.date.updated | 2023-12-10T07:17:13Z | |
local.identifier.scopusID | 2-s2.0-85016744587 | |
local.identifier.thomsonID | WOS:000398786700013 | |
Collections | ANU Research Publications |
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