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MALT1 is an intrinsic regulator of regulatory T cells

Bruestle, Anne; Brenner, Dirk; Knobbe-Thomsen, CB; Cox, M; Lang, P A; Lang, KS; Mak, Tak W

Description

Regulatory T cells (Tregs) are crucial for the maintenance of immunological self-tolerance and their absence or dysfunction can lead to autoimmunity. However, the molecular pathways that govern Treg biology remain obscure. In this study, we show that the nuclear factor-κB signalling mediator mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is an important novel regulator of both Tregs originating in the thymus (‘natural’ or nTregs) and Tregs induced to differentiate...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
URI: http://hdl.handle.net/1885/242798
Source: Cell Death and Differentiation
DOI: 10.1038/cdd.2015.104
Access Rights: Open Access

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