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Longitudinal study of clinical prognostic factors in patients with early rheumatoid arthritis: the PREDICT study

Bird, Paul; Nichols, Dave; Nicholls, Dave; Barrett, Rina; de Jager, Julien; Griffiths, Hedley; Roberts, L; Tymms, Kathleen; McCloud, Philip; Littlejohn, Geoffrey

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Aim: To assess the association between baseline clinical prognostic factors and subsequent Disease Activity Scoreof 28 joints (DAS28) remission in early rheumatoid arthritis (RA).Methods: Data were collected using point of care clinical software from participating rheumatology centres.Patients aged 18 years or over whose date of clinical onset of RA was within the previous 12–24 months, whohad at least 6 months of follow-up data and a DAS28-ESR (erythrocyte sedimentation rate) score...[Show more]

dc.contributor.authorBird, Paul
dc.contributor.authorNichols, Dave
dc.contributor.authorNicholls, Dave
dc.contributor.authorBarrett, Rina
dc.contributor.authorde Jager, Julien
dc.contributor.authorGriffiths, Hedley
dc.contributor.authorRoberts, L
dc.contributor.authorTymms, Kathleen
dc.contributor.authorMcCloud, Philip
dc.contributor.authorLittlejohn, Geoffrey
dc.date.accessioned2021-08-02T23:57:00Z
dc.identifier.issn1756-1841
dc.identifier.urihttp://hdl.handle.net/1885/242600
dc.description.abstractAim: To assess the association between baseline clinical prognostic factors and subsequent Disease Activity Scoreof 28 joints (DAS28) remission in early rheumatoid arthritis (RA).Methods: Data were collected using point of care clinical software from participating rheumatology centres.Patients aged 18 years or over whose date of clinical onset of RA was within the previous 12–24 months, whohad at least 6 months of follow-up data and a DAS28-ESR (erythrocyte sedimentation rate) score recordedbetween 12 and 24 months from first being seen for RA were included. Data collected included baseline demo-graphics, mode of disease onset, pattern of joint involvement at onset, smoking status, DAS28, rheumatoid fac-tor (RF), anti-citrullinated peptide antibodies (ACPA), time from symptom onset to presentation and diseaseactivity at baseline. Univariate and multivariate logistic regression of DAS28-ESR remission between 12 and24 months after first assessment were performed.Results: Data from 1017 patients were analyzed: 70% female; mean age 60 years (SD: 14.7); 70% RF-positive,58% ACPA-positive. The strongest age and sex adjusted baseline predictors of DAS28-ESR remission at 12–24 months were remission at baseline (odds ratio [OR]: 4.49, 95% CI: 2.17 –9.29, P < 0.001), being male (OR:2.42, 95% CI: 1.46 –4.01, P < 0.001), abstaining from alcohol (P < 0.001) and being lower weight (OR: 0.98,95% CI: 0.97–1.00, P = 0.015). There was no statistically significant association between joint onset patterns,mode of onset, RF, ACPA or smoking status.Conclusion: In this observational study, patients with early RA at risk of not achieving remission include thosewith high disease activity at baseline, women, those who drink alcohol and those with higher body weight.
dc.description.sponsorshipThe study was supported by Roche Products Pty Ltd (Australia).
dc.format.mimetypeapplication/pdf
dc.language.isoen_AU
dc.publisherWiley
dc.rights© 2017 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd
dc.sourceInternational Journal of Rheumatic Diseases
dc.subjectprognostic factors
dc.subjectremission
dc.subjectrheumatoid arthritis
dc.subjectrheumatoid factor
dc.titleLongitudinal study of clinical prognostic factors in patients with early rheumatoid arthritis: the PREDICT study
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume20
dc.date.issued2017
local.identifier.absfor110799 - Immunology not elsewhere classified
local.identifier.ariespublicationu5234101xPUB80
local.publisher.urlhttps://www.wiley.com/en-gb
local.type.statusPublished Version
local.contributor.affiliationBIRD, Paul, Combined Rheumatology Practice
local.contributor.affiliationNichols, Dave, Coast Joint Care
local.contributor.affiliationNicholls, Dave, Coast Joint Care
local.contributor.affiliationBarrett, Rina, Roche Products Pty Limited
local.contributor.affiliationde Jager, Julien, Gold Coast Rheumatology
local.contributor.affiliationGriffiths, Hedley, Barwon Rheumatology Service
local.contributor.affiliationRoberts, L, Monash University
local.contributor.affiliationTymms, Kathleen, College of Health and Medicine, ANU
local.contributor.affiliationMcCloud, Philip, McCloud Consulting Group
local.contributor.affiliationLittlejohn, Geoffrey, Monash University
local.description.embargo2099-12-31
local.bibliographicCitation.issue4
local.bibliographicCitation.startpage460
local.bibliographicCitation.lastpage468
local.identifier.doi10.1111/1756-185X.13036
local.identifier.absseo920199 - Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified
dc.date.updated2020-11-23T10:46:19Z
CollectionsANU Research Publications

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