Dahlke, Marc H; Loi, Roberto; Warren, Alessandra; Holz, Lauren; Popp, Felix C; Weiss, Daniel J; Piso, Pompiliu; Bowen, David G; McCaughan, Geoffrey W; Schlitt, Hans J; Bertolino, Patrick
Background/Aims: The role of adult bone marrow-derived cells (BMC) in hepatic regeneration is controversial. Both transdifferentiation of BMC as well as fusion with hepatocytes have been suggested in toxin-based and genetic selection models. Methods: We have developed a transgenic mouse model of immune-mediated hepatitis to clarify the role of BMC in liver regeneration following injury mediated by T cells. Results: Repeated adoptive transfer of transgenic T cells into bone marrow chimeras...[Show more]
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.