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Immune-mediated hepatitis drives low-level fusion between hepatocytes and adult bone marrow cells

Dahlke, Marc H; Loi, Roberto; Warren, Alessandra; Holz, Lauren; Popp, Felix C; Weiss, Daniel J; Piso, Pompiliu; Bowen, David G; McCaughan, Geoffrey W; Schlitt, Hans J; Bertolino, Patrick


Background/Aims: The role of adult bone marrow-derived cells (BMC) in hepatic regeneration is controversial. Both transdifferentiation of BMC as well as fusion with hepatocytes have been suggested in toxin-based and genetic selection models. Methods: We have developed a transgenic mouse model of immune-mediated hepatitis to clarify the role of BMC in liver regeneration following injury mediated by T cells. Results: Repeated adoptive transfer of transgenic T cells into bone marrow chimeras...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: Journal of Hepatology
DOI: 10.1016/j.jhep.2005.07.023


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