Crouch, Michael F
Heterotrimeric GTP-binding proteins (G-proteins) are involved in a diverse array of signalling path-ways. They are generally thought to be membrane-bound proteins, which disassociate on receptor activation and binding of GTP. A model to explain this has been proposed, which is often described as 'the G-protein cycle'. The 'G-protein cycle' is discussed in the present paper in relation to evidence that now exists regarding the non-membranous localization of G-proteins. Specifically, the...[Show more]
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