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Leptin Replacement Prevents Weight Loss-Induced Metabolic Adaptation in Congenital Leptin-Deficient Patients

Galgani, Jose E.; Greenway, Frank L; Caglayan, Sinan; Wong, Ma-Li; Licinio, Julio; Ravussin, Eric


Context: Leptin regulates energy homeostasis by suppressing food intake; however, its role in energy expenditure and fat oxidation remains uncertain in humans. Objective: The aim of the study was to assess 24-h energy metabolism before and after weight loss induced by leptin treatment in congenital leptin-deficient subjects or low-calorie diet in controls. Design and Patients: We measured 24-h energy expenditure, 24-h fat oxidation, and body fat in three null homozygous leptin-deficient obese...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Journal of Clinical Endocrinology and Metabolism
DOI: 10.1210/jc.2009-1739


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