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Role of laeA in the regulation of alb1, gliP , Conidial Morphology and Virulence in Aspergillus fumigatus

Sugui, Janyce; Pardo, Julian; Chang, Yun C.; Mullbacher, Arno; Zarember, Kol A; Galvez, Eva; Brinster, Lauren; Zerfas, Patricia; Gallin, John I; Simon, Markus M; Kwon-Chung, June Kyung


The alb1 (pksP) gene has been reported as a virulence factor controlling the pigmentation and morphology of conidia in Aspergillus fumigatus. A recent report suggested that laeA regulates alb1 expression and conidial morphology but not pigmentation in the A. fumigatus strain AF293. laeA has also been reported to regulate the synthesis of secondary metabolites, such as gliotoxin. We compared the role of laeA in the regulation of conidial morphology and the expression of alb1 and gliP in strains...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Eukaryotic Cell
DOI: 10.1128/EC.00140-07


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