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Leptin signals via TGFB1 to promote metastatic potential and stemness in breast cancer

Mishra, Ameet; Parish, Christopher; Wong, Ma-Li; Licinio, Julio; Blackburn, Anneke


Epidemiological studies have shown obesity to be linked with poorer outcomes in breast cancer patients. The molecular mechanisms responsible for the increased risk of invasive/metastatic disease with obesity are complex, but may include elevated levels of adipokines such as leptin. Using physiological levels of leptin found in obesity in a novel chronic in vitro treatment model (≤200 ng/ml for 14 days), we confirmed the occurrence of leptin-mediated changes in growth, apoptosis and metastatic...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
Source: PLOS ONE (Public Library of Science)
DOI: 10.1371/journal.pone.0178454
Access Rights: Open Access


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