Skip navigation
Skip navigation

Differential Drug Responses on Native GABAa Receptors Revealing Heterogeneity in Extrasynaptic Populations in Cultured Hippocampal Neurons

Seymour, Victoria; Everitt, Andrea; Tierney, Mary (Louise)


Hippocampal pyramidal neurons potentially express multiple subtypes of GABAA receptors at extrasynaptic locations that could therefore respond to different drugs. We activated extrasynaptic GABAA receptors in cultured rat hippocampal pyramidal neurons and measured single-channel currents in order to compare the actions of two drugs that potentially target different GABAA receptor subtypes. Despite the possible difference in receptor targets of etomidate and diazepam, the two drugs were similar...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: Journal of Membrane Biology
DOI: 10.1007/s00232-008-9150-4


File Description SizeFormat Image
01_Seymour_Differential_Drug_Responses_on_2009.pdf464.12 kBAdobe PDF    Request a copy

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  20 July 2017/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator