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Differential Drug Responses on Native GABAa Receptors Revealing Heterogeneity in Extrasynaptic Populations in Cultured Hippocampal Neurons

Seymour, Victoria; Everitt, Andrea; Tierney, Mary (Louise)


Hippocampal pyramidal neurons potentially express multiple subtypes of GABAA receptors at extrasynaptic locations that could therefore respond to different drugs. We activated extrasynaptic GABAA receptors in cultured rat hippocampal pyramidal neurons and measured single-channel currents in order to compare the actions of two drugs that potentially target different GABAA receptor subtypes. Despite the possible difference in receptor targets of etomidate and diazepam, the two drugs were similar...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: Journal of Membrane Biology
DOI: 10.1007/s00232-008-9150-4


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