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Hemodynamics of dexamethasone-induced hypertension in the rat

Ong, Sharon; Zhang, Yi; Sutton, Matthew; Whitworth, Judith

Description

Although dexamethasone (DEX) is known to cause hypertension in humans and in animals, the hemodynamic characteristics of DEX-induced hypertension (DEX-HT) in the rat remain unclear. This study evaluated central and regional hemodynamics, and the role of total peripheral resistance (TPR) using a vasodilator minoxidil. Rats were divided into four groups, namely saline (n=20), DEX (n=21), minoxidil+saline (n=10) and minoxidil+DEX (n=10). Tail-cuff systolic blood pressure was recorded every second...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
URI: http://hdl.handle.net/1885/23979
Source: Hypertension Research
DOI: 10.1038/hr.2009.118

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