Takahashi, Hisaaki; Matsumoto, Hiroaki; Kumon, Yoshiaki; Ohnishi, Takanori; Freeman, Craig; Imai, Yoshinori; Tanaka, Junya
Heparanase is an enzyme that cleaves heparan sulfate proteoglycans, an important component of the extracellular matrix to generate heparan sulfate fragments, leading to the remodeling of the extracellular matrix and the basement membrane particularly during cancer metastasis. A growing body of evidence suggests that heparanase serves multiple functions in normal tissues including the central nervous system. In this study, we showed that heparanase is expressed in reactive astrocytes in the...[Show more]
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