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Heparan sulfate as a receptor for poxvirus infections and as a target for antiviral agents

Khanna, Mayank; Ranasinghe, Charani; Jackson, Ronald; Parish, Christopher


To establish the importance of virus–heparan sulfate (HS) interactions in virus infectivity, the poxvirus vaccinia virus (VACV) was used, as it binds HS and has both enveloped virus (EV) and non-enveloped mature virus (MV) forms. Initial studies showed that heparin inhibited plaque formation by both MV-rich WR and EV-rich IHD-J strains of VACV, with the EV-rich strain also losing trademark ‘comet’-shaped plaques. However, using GFP-tagged EV and MV forms of VACV, based on IC50 values, heparin...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
Source: Journal of General Virology
DOI: 10.1099/jgv.0.000921
Access Rights: Open Access


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