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Healthcare-Associated Clostridium difficile Infections are Sustained by Disease from the Community

McLure, Angus; Clements, Archie; Kirk, Martyn; Glass, Katie


Clostridium difficile infections (CDIs) are some of the most common hospital-associated infections worldwide. Approximately 5% of the general population is colonised with the pathogen, but most are protected from disease by normal intestinal flora or immune responses to toxins. We developed a stochastic compartmental model of CDI in hospitals that captures the condition of the host’s gut flora and the role of adaptive immune responses. A novel, derivative-based method for sensitivity analysis...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
Source: Bulletin of Mathematical Biology
DOI: 10.1007/s11538-017-0328-8


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