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Glutathione Primes T Cell Metabolism for Inflammation

Mak, Tak W; Grusdat, Melanie; Duncan, GS; Dostert, Catherine; Nonnenmacher, Yannic; Cox, Maureen; Binsfeld, Carole; Hao, Zhenyue; Bruestle, Anne; Itsumi, Momoe; Jager, Christian; Chen, Ying; Pinkenburg, Olaf; Camara, B; Ollert, Markus; Bindslev-Jensen, Carsten; Vasiliou, Vasilis; Gorrini, Chiara; Lang, Phillip A; Lohoff, Michael; Harris, Isaac S; Hiller, Karsten; Brenner, Dirk


Activated T cells produce reactive oxygen species (ROS), which trigger the antioxidative glutathione (GSH) response necessary to buffer rising ROS and prevent cellular damage. We report that GSH is essential for T cell effector functions through its regulation of metabolic activity. Conditional gene targeting of the catalytic subunit of glutamate cysteine ligase (Gclc) blocked GSH production specifically in murine T cells. Gclc-deficient T cells initially underwent normal activation but could...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
Source: Immunity
DOI: 10.1016/j.immuni.2017.03.019


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