Genetic variation in the gene LRP2 increases relapse risk in multiple sclerosis
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Zhou, Yuan; Graves, Jennifer S; Simpson Jr, S; Charlesworth, Jac C; Van Der Mei, Ingrid; Waubant, Emmanuelle; Barcellos, Lisa F; Belman, Anita; Krupp, Lauren; Lucas, Robyn; Ponsonby, Anne-Louise; Taylor, Bruce V
Description
Background Due to the lack of prospective studies with longitudinal data on relapse, past genetic studies have not attempted to identify genetic factors that predict relapse risk (the primary endpoint of many pivotal clinical trials testing the efficacy of multiple sclerosis (MS) disease-modifying drugs) at a genome-wide scale. Methods We conducted a genome-wide association analysis (GW AS) to identify genetic variants that predict MS relapse risk, using a three-stage approach....[Show more]
Collections | ANU Research Publications |
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Date published: | 2017 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/238318 |
Source: | Journal of Neurology, Neurosurgery & Psychiatry |
DOI: | 10.1136/jnnp-2017-315971 |
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01_Zhou_Genetic_variation_in_the_gene_2017.pdf | 894.42 kB | Adobe PDF | Request a copy |
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