GABAB receptors in neocortical and hippocampal pyramidal neurons are coupled to different potassium channels
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Breton, Jean-Didier; Stuart, Greg
Description
Classically, GABAB receptors are thought to regulate neuronal excitability via G-protein-coupled inwardly rectifying potassium (GIRK) channels. Recent data, however, indicate that GABAB receptors can also activate two-pore domain potassium channels. Here, we investigate which potassium channels are coupled to GABAB receptors in rat neocortical layer 5 and hippocampal CA1 pyramidal neurons. Bath application of the non-specific GIRK channel blocker barium (200 μm) abolished outward currents...[Show more]
Collections | ANU Research Publications |
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Date published: | 2017 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/238281 |
Source: | European Journal of Neuroscience |
DOI: | 10.1111/ejn.13777 |
Access Rights: | Open Access |
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File | Description | Size | Format | Image |
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ejn.13777.pdf | Author Accepted Manuscript | 371.34 kB | Adobe PDF |
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