The role of 20-hydroxyeicosatetraenoic acid in adrenocorticotrophic hormone and dexamethasone-induced hypertension
Zhang, Yi; Wu, Jason H Y; Vickers, Janine; Ong, Sharon; Temple, Suzanna E L; Mori, Trevor A; Croft, Kevin D; Whitworth, Judith
OBJECTIVE: 20-hydroxyeicosatetraenoic acid (20-HETE) is a potent constrictor in small arteries and also has natriuretic properties. Urinary 20-HETE excretion is increased in adrenocorticotrophic hormone (ACTH)-induced hypertensive rats. In the present study, we investigated the effect of a specific enzyme inhibitor of 20-HETE production, N-hydroxy-N′-(4-butyl-2- methylphenyl) formamidine (HET0016), on glucocorticoid-induced hypertension in rats, a sodium-independent model. METHODS: Male...[Show more]
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|Source:||Journal of Hypertension|
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