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Epidemic of Pathologic Myopia : What Can Laboratory Studies and Epidemiology Tell Us?

Morgan, Ian; He, Mingguang; Rose, Kathryn A

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Purpose: To systematically review epidemiologic and laboratory studies on the etiology of high myopia and its links to pathologic myopia. Methods: Regular Medline searches have been performed for the past 20 years, using "myopia" as the basic search term. The abstracts of all articles have been scrutinized for relevance, and where necessary, translations of articles in languages other than English were obtained. Results: Systematic review shows that there is an epidemic of myopia and high...[Show more]

dc.contributor.authorMorgan, Ian
dc.contributor.authorHe, Mingguang
dc.contributor.authorRose, Kathryn A
dc.date.accessioned2021-06-16T03:56:44Z
dc.identifier.issn0275-004X
dc.identifier.urihttp://hdl.handle.net/1885/237389
dc.description.abstractPurpose: To systematically review epidemiologic and laboratory studies on the etiology of high myopia and its links to pathologic myopia. Methods: Regular Medline searches have been performed for the past 20 years, using "myopia" as the basic search term. The abstracts of all articles have been scrutinized for relevance, and where necessary, translations of articles in languages other than English were obtained. Results: Systematic review shows that there is an epidemic of myopia and high myopia in young adults in East and Southeast Asia, with similar but smaller trends in other parts of the world. This suggests an impending epidemic of pathologic myopia. High myopia in young adults in East and Southeast Asia is now predominantly associated with environmental factors, rather than genetic background. Recent clinical trials show that the onset of myopia can be reduced by increasing the time children spend outdoors, and methods to slow the progression of myopia are now available. Conclusion: High myopia is now largely associated with environmental factors that have caused the epidemic of myopia in East and Southeast Asia. An important clinical question is whether the pathologic consequences of acquired high myopia are similar to those associated with classic genetic high myopia. Increased time outdoors can be used to slow the onset of myopia, whereas methods for slowing progression are now available clinically. These approaches should enable the current epidemics of myopia and high myopia to be turned around, preventing an explosion of pathologic myopia.
dc.format.mimetypeapplication/pdf
dc.language.isoen_AU
dc.publisherLippincott Williams & Wilkins
dc.rights© Ophthalmic Communications Society, Inc.
dc.sourceRetina: the Journal of Retinal and Vitreous diseases
dc.subjectmyopia
dc.subjecthigh myopia
dc.subjectpathology
dc.subjectprevention
dc.subjecttime outdoors
dc.subjectatropine
dc.titleEpidemic of Pathologic Myopia : What Can Laboratory Studies and Epidemiology Tell Us?
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume37
dc.date.issued2017
local.identifier.absfor111301 - Ophthalmology
local.identifier.ariespublicationU3488905xPUB24880
local.publisher.urlhttp://www.retinajournal.com/
local.type.statusPublished Version
local.contributor.affiliationMorgan, Ian, College of Science, ANU
local.contributor.affiliationHe, Mingguang, University of Melbourne
local.contributor.affiliationRose, Kathryn A, University of Technology Sydney
local.description.embargo2099-12-31
local.bibliographicCitation.issue5
local.bibliographicCitation.startpage989
local.bibliographicCitation.lastpage997
local.identifier.doi10.1097/IAE.0000000000001272
dc.date.updated2020-11-23T10:29:38Z
local.identifier.scopusID2-s2.0-84987602224
local.identifier.thomsonID000402173400041
CollectionsANU Research Publications

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