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Emerging activators and regulators of inflammasomes and pyroptosis

Xue, Yansong; Enosi Tuipulotu, Daniel; Tan, Wei Hong; Kay, Callum; Man, Si Ming


The inflammasome is a cytosolic immune signaling complex that induces inflammation and pyroptosis. Inflammasome complexes respond to a variety of pathogens, as well as danger or homeostasis-altering signals; they can play critical roles in the development of autoinflammatory conditions and cancer. Studies have now provided additional insights into the activation mechanisms and regulation of established inflammasome complexes, including NLRP1b, NLRP3, NOD-like receptor family apoptosis...[Show more]

CollectionsANU Research Publications
Date published: 2019
Type: Journal article
Source: Trends in Immunology
DOI: 10.1016/
Access Rights: Open Access


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