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DOCK8 regulates signal transduction events to control immunity

Kearney, Connor J; Randall, Katrina; Oliaro, Jane

Description

Genetic mutations in the gene encoding DOCK8 cause an autosomal recessive form of hyper immunoglobulin E syndrome (AR-HIES), referred to as DOCK8 deficiency. DOCK8 deficiency in humans results in the onset of combined immunodeficiency disease (CID), clinically associated with chronic infections with diverse microbial pathogens, and a predisposition to malignancy. It is now becoming clear that DOCK8 regulates the function of diverse immune cell sub-types, particularly lymphocytes, to drive both...[Show more]

dc.contributor.authorKearney, Connor J
dc.contributor.authorRandall, Katrina
dc.contributor.authorOliaro, Jane
dc.date.accessioned2021-06-09T00:28:33Z
dc.identifier.issn1672-7681
dc.identifier.urihttp://hdl.handle.net/1885/236883
dc.description.abstractGenetic mutations in the gene encoding DOCK8 cause an autosomal recessive form of hyper immunoglobulin E syndrome (AR-HIES), referred to as DOCK8 deficiency. DOCK8 deficiency in humans results in the onset of combined immunodeficiency disease (CID), clinically associated with chronic infections with diverse microbial pathogens, and a predisposition to malignancy. It is now becoming clear that DOCK8 regulates the function of diverse immune cell sub-types, particularly lymphocytes, to drive both innate and adaptive immune responses. Early studies demonstrated that DOCK8 is required for lymphocyte survival, migration and immune synapse formation, which translates to poor pathogen control in the absence of DOCK8. However, more recent advances have pointed to a crucial role for DOCK8 in regulating the signal transduction events that control transcriptional activity, cytokine production and functional polarization of immune cells. Here, we summarize recent advances in our understanding of DOCK8 function, paying particular attention to an emerging role as a signaling intermediate to promote immune responses to diverse external stimuli.
dc.format.mimetypeapplication/pdf
dc.language.isoen_AU
dc.publisherChinese Society of Immunology
dc.rights© 2017 CSI and USTC
dc.sourceCellular and Molecular Immunology
dc.subjectDOCK8
dc.subjectimmunodeficiency
dc.subjectlymphocytes
dc.subjectNK Cells
dc.subjectsignal transduction
dc.titleDOCK8 regulates signal transduction events to control immunity
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume14
dc.date.issued2017
local.identifier.absfor110704 - Cellular Immunology
local.identifier.ariespublicationa383154xPUB7017
local.publisher.urlhttp://www.nature.com/cmi/
local.type.statusPublished Version
local.contributor.affiliationKearney, Connor J, Peter MacCallum Caner Centre
local.contributor.affiliationRandall, Katrina, College of Health and Medicine, ANU
local.contributor.affiliationOliaro, Jane, Peter MacCallum Cancer Centre
local.description.embargo2099-12-31
local.bibliographicCitation.issue5
local.bibliographicCitation.startpage406
local.bibliographicCitation.lastpage411
local.identifier.doi10.1038/cmi.2017.9
dc.date.updated2020-11-23T10:26:34Z
local.identifier.scopusID2-s2.0-85019131737
local.identifier.thomsonID000400901300003
CollectionsANU Research Publications

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