DOCK8 regulates signal transduction events to control immunity
Genetic mutations in the gene encoding DOCK8 cause an autosomal recessive form of hyper immunoglobulin E syndrome (AR-HIES), referred to as DOCK8 deficiency. DOCK8 deficiency in humans results in the onset of combined immunodeficiency disease (CID), clinically associated with chronic infections with diverse microbial pathogens, and a predisposition to malignancy. It is now becoming clear that DOCK8 regulates the function of diverse immune cell sub-types, particularly lymphocytes, to drive both...[Show more]
|Collections||ANU Research Publications|
|Source:||Cellular and Molecular Immunology|
|01_Kearney_DOCK8_regulates_signal_2017.pdf||768.96 kB||Adobe PDF||Request a copy|
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