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DOCK8 regulates signal transduction events to control immunity

Kearney, Connor J; Randall, Katrina; Oliaro, Jane


Genetic mutations in the gene encoding DOCK8 cause an autosomal recessive form of hyper immunoglobulin E syndrome (AR-HIES), referred to as DOCK8 deficiency. DOCK8 deficiency in humans results in the onset of combined immunodeficiency disease (CID), clinically associated with chronic infections with diverse microbial pathogens, and a predisposition to malignancy. It is now becoming clear that DOCK8 regulates the function of diverse immune cell sub-types, particularly lymphocytes, to drive both...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
Source: Cellular and Molecular Immunology
DOI: 10.1038/cmi.2017.9


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