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Does chronomodulated radiotherapy improve pathological response in locally advanced rectal cancer?

Squire, Tim; Buchanan, Grant; Rangiah, David; Davis, Ian; Yip, Desmond; Chua, YuJo; Rich, Tyvin; Elsaleh, Hany


The predominant mode of radiation-induced cell death for solid tumours is mitotic catastrophe, which is in part dependent on sublethal damage repair being complete at around 6 h. Circadian variation appears to play a role in normal cellular division, and this could influence tumour response of radiation treatment depending on the time of treatment delivery. We tested the hypothesis that radiation treatment later in the day may improve tumour response and nodal downstaging in rectal cancer...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
Source: Chronobiology International
DOI: 10.1080/07420528.2017.1301462


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